Takes 2 minutes. Get personalized insights based on your symptoms
Explore expert conversations on hormones, metabolism, weight loss, peptides, gut health, and longevity. Get practical insights to help you feel better, age stronger, and take control of your health.
In this episode, Dr. Cassie Smith sits down with our host, Joe Miller, founder of First Optimal, to discuss the powerful connection between gut health, hormones, metabolism, and overall wellness. We talk about root causes, advanced testing, sustainable lifestyle changes, and why your symptoms may be telling you more than your lab results.
Latest Episode
3 weeks ago
53:33
4 months ago
01:15:01
4 months ago
49:03
4 months ago
01:02:25
1 month ago
57:56
1 month ago
26:24
2 months ago
1:15:05
2 months ago
58:25
2 months ago
1:37:13
2 months ago
43:35
2 months ago
1:08:17
Peptide therapy is now discussed everywhere from medical practices and podcasts to gyms and social media. That attention has created legitimate interest, but it has also blurred important distinctions between FDA-approved peptide medications, lawfully compounded prescriptions, investigational compounds, and products sold online as “research use only.” These categories do not carry the same evidence, manufacturing […]
Fatigue is one of the most common and frustrating health complaints. It may feel like low physical energy, mental exhaustion, poor exercise tolerance, daytime sleepiness, brain fog, or an inability to recover after normal activity. The problem is that fatigue is not a diagnosis. It is a signal. A thoughtful functional medicine fatigue panel may […]
When you stop a glucagon-like peptide-1 medication, its appetite, fullness, digestion, and blood sugar effects gradually fade. Hunger and food cravings may increase, gastrointestinal side effects may improve, and weight regain becomes more likely. This does not mean everyone regains all the weight they lost. It does mean that stopping without a maintenance strategy can […]
Author: Joe Miller, Founder of 1st Optimal Medically reviewed by: Franchell Hamilton, MD, FACS, FASMBS, DABOM Quick Answer: A 2026 systematic review found that testosterone therapy was associated with improvements in sexual desire, libido, sexual satisfaction, and satisfactory sexual experiences in women. The strongest evidence came from randomized clinical trials involving postmenopausal women. Results in […]
You step on the scale after a week of eating well, training consistently, and doing everything you thought you were supposed to do. The number is unchanged. Or worse, it went up. So naturally, you assume the plan is failing. But what if your waist is smaller? What if your clothes fit better? What if […]
Peptides are having their moment. They’re being promoted for faster recovery, better sleep, improved metabolism, stronger muscles, younger-looking skin, mitochondrial health, gut repair, hormone support, and even longer life. Depending on who you follow online, peptides are either the next major chapter in precision medicine or a refrigerated box of expensive optimism. The honest answer […]
